Organogenesis has the skinny on replacement tissue. Flagship product Apligraf is a human skin substitute approved to treat diabetic foot ulcers and venous leg ulcers caused by poor circulation. Rejection-resistant Apligraf is bio-engineered using living skin cells and has been used to treat chronic open wounds in some 250,000 patients; the company is developing a next-generation version of the material (using its VCT technology) using all human components. In addition to Apligraf, Organogenesis offers a line of biomaterials used in a range of surgical procedures to seal or reconstruct soft tissue, and it also develops regenerative technologies in the area of cosmetic skin rejuvenation.

Ormco develops and distributes a variety of orthodontic equipment and supplies, including adhesives, cutting instruments, bands and crowns, brackets, trays, and wires. Its brands include Damon System, Grengloo, STb Light Lingual System, and Titanium Orthos. The company distributes its products directly and through distributors in the US and around the globe. Ormco also offers products through its online catalog. Danaher controls the company and its immediate parent firm Sybron Dental Specialties.

OrSense makes non-invasive medical monitoring equipment, based on a technology called Occlusion Spectroscopy, that measures levels of blood glucose and hemoglobin via a ring-shaped cuff, which generates a readable transmission signal when placed on the finger. Patients can self-test with OrSense's devices, which are useful for anemia screening and diabetes monitoring. Biophysicist and company CTO Ilya Fine founded OrSense in 1996 after inventing its core technology. Leading investors include STAR Ventures and Israel Health Care Ventures.

Ortho-Clinical Diagnostics earns an A+ in Chemistry. The Johnson & Johnson subsidiary develops and markets diagnostic tools, including VITROS instrumentation systems that use clinical chemistry and immunoassay technologies to diagnose a range of maladies such as cancer, heart disease, and infectious diseases. It also markets laboratory automation systems under the enGen brand. In addition to making clinical diagnostics products, Ortho-Clinical Diagnostics is a leading maker of instruments and reagents used by blood banks and hospitals to screen blood donations for disease and contaminants, as well as blood typing systems that guarantee patient-donor compatibility for transfusions.

Orthofix International N.V. makes a variety of spinal and orthopedic devices and sports medicine products used to immobilize and patch bone, as well as stimulate new growth. Its products include Firebird spinal fixation systems, Spinal-Stim bone growth stimulator, TRUE/LOK ring fixation systems for limbs, BREG Bracing limb support, and Trinity Evolution, a stem-cell based bone grafting material. The company also produces a system to improve blood flow in immobilized patients. Orthofix sells its products to healthcare providers through subsidiaries and independent distributors in Brazil, Europe, Mexico, and the US.

Osteotech uses donated human tissue (also known as allograft) to make bone repair, replacement, and regeneration products for the orthopedic, neurological, oral/maxillofacial, and dental surgery markets around the globe. Its Grafton brand of bone matrix comes in gel, sheet, putty, and even chip form to fill bone defects and induce bone growth. Other marketed products include Magnifuse graft material and FacetLinx for spinal fusion. Additionally, Osteotech processes bovine tissue (xenografts) for use as bone grafts. The company is owned by medical device maker Medtronic.

OstoMART sells, and delivers to the home, a range of garments and prescription products across the UK to ostomy patients. (An ostomy is a surgical opening in the body for releasing body wastes). OstoMART has service centers in Larne, Nottingham, and Peterborough. Products include ostomy pouch covers, adhesive tape, protection shields, and other specialized supplies. OstoMART also manufactures and sells support garments, underwear, and swimwear. The company was established in 1991 by nurse Dorothy Waller.

Otix Global brings the world to the hearing impaired. The company designs, manufactures, and markets digital hearing aids. Its brands include Applause, Balance, Natura, Quartet, Sonic, Tribute, and Velocity. As its technology advances, the company has expanded with variations on both behind-the-ear and in-the-canal hearing aids including its small receiver-in-the-canal product under the Touch brand. The company sells its products to hearing care professionals and directly to individuals through a handful of retail audiology outlets in Australia, Europe, and the US. Otix Global is the subject of a bidding war between two Danish hearing aid makers, William Demant and GN ReSound.

Otto Bock HealthCare offers mobility options for disabled patients. The company makes and distributes prosthetic and orthotic equipment, including leg braces, electronic hands and shoulders, and cosmetic false limbs, as well as implantable neurostimulation devices. Otto Bock HealthCare also manufactures mobility and seating devices for disabled adults and children, including wheelchairs, positioning supports, and standing devices. Its products are marketed worldwide through internal and external sales representatives. The company is controlled by descendants of founder Otto Bock, who launched the business in 1919.

Otto Bock Healthcare PLC manufactures and distributes a range of prosthetic, orthotic, and other medical devices in the UK. Its products include prosthetic limbs, joints, breasts, and extremities; wheelchairs, custom seating, walkers, support and compression stockings, back support bandages, and shower seats. The majority of Otto Bock's products are distributed in the UK through NHS and private rehabilitation facitilities. The company is a subsidiary of German firm Otto Bock Healthcare GmbH.

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