William Beaumont Hospital draws on a rich history of pioneering medical research to serve the health needs of southeastern Michigan and advance healing techniques nationwide. William Beaumont Hospital consists of three hospitals with more than 1,700 beds in suburban Detroit. Other facilities include nursing homes, a home health care agency, a research institute, and primary and specialty care clinics, as well as rehabilitation, cardiology, and cancer centers. The hospitals are affiliated with the medical schools of institutions including the University of Michigan and Wayne State University.

AGA Medical Holdings works to heal broken hearts. The company specializes in making medical devices for treating structural heart defects and vascular diseases. Its AMPLATZER occlusion devices use minimally invasive small catheters, which physicians can retrieve and position without the need for multiple devices or repetition of procedures. Approved for use in both Europe and the US, the company sell its devices in more than 100 countries. Its primary customers are pediatric cardiologists, radiologists, and vascular surgeons. Dr. Kurt Amplatz and director Franck Gougeon established AGA Medical Holdings in 1995. AGA Medical is being acquired bySt. Jude Medical.

KishHealth System takes care of the welfare of people all along the "Kish." Formerly Kishwaukee Health System, KishHealth System operates two community hospitals -- Kishwaukee and Valley West, which have a combined 125 staffed beds -- as well as several cancer centers, imaging facilities, and an eye institute that serve Dekalb County and surrounding areas in northern Illinois. Specialty services include cardiology, emergency care, neurosurgery, obstetrics, and orthopedics. The community-owned health system takes its name from Kishwaukee (a Potowatomi word for "river of the sycamore").

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Fresenius Kabi AG,a subsidiary of Fresenius SE -- to which it contributes more than 15% of its annual sales -- the unit is a leading provider of a variety of transfusion products and devices. Fresenius Kabi's Voluven product is the top-selling artificial colloid -- a blood volume substitute used after trauma -- outside North America. Other infusion products include products for fluid and blood replacement, generic anesthetics and other IV-administered drugs, and medical devices such as insulin delivery pumps. Fresenius Kabi also produces clinical nutrition products for patients who are unable to digest normal food.

Shasta Regional Medical Center serves counties in northern California. The medical center offers a variety of services in areas such as surgical and critical care, emergency and trauma, and cardiac care. It has a capacity of about 250 beds. Specialty units include the complex's Chest Pain Center, Vascular Wellness Center, and Cardiovascular Catheterization Laboratory. Other services include diabetes care, neurosciences, orthopedics, radiology, and oncology. Shasta Regional is operated by hospital management firm Prime Healthcare Services.

Northwestern Memorial Hospital can get you upright again. Part of corporate parent Northwestern Memorial HealthCare (NMHC), the teaching hospital serves residents of the Chicago area, offering virtually every medical specialty. Northwestern Memorial hospital has more than 850 beds and is affiliated with Northwestern University's Feinberg School of Medicine. It encompasses an ambulatory surgery center, physicians' practices, community clinics, a home hospice program, and health and wellness centers. Other subsidiaries of the NMHC health system include a primary care medical group practice, a philanthropic foundation, an insurance company, and a managed care contracts provider.

Pennine Healthcare products may be disposable, but they're anything but dispensable. The company makes sterile, single use medical devices, manufacturing more than 50 million per year at its facilities in Derby. The disposable products are designed for applications in airway management (suction catheters, mucus extractors), gastroenterology (stomach tubes, bile bags), respiratory uses (filters, oxygen therapy), surgical suction (tubes and probes), and urology (various types of catheters). The firm also offers custom procedure packs for surgical procedures. Its products are sold by third-party distributors throughout the UK and in more than 70 countries.

Q-Med seeks a smooth future, but thus far it still has a few wrinkles in its plans. The company develops and manufactures the high-tech goo Restylane dermatologists inject to fill in lines and creases in facial skin. Its Durolane product, also based on its non-animal sourced hyaluronic acids, is used as an injection to treat osteoarthritis of the knee. Its products are distributed in over 70 countries, but only Restylane has received FDA approval for use in the US. The Swedish company entered the US exchanges by buying up the shell of a public company in 2008.

Bruker AXS helps companies X-ray their way to the next hot drug. The firm makes X-ray systems that can analyze the structure of small molecules and aid in drug discovery and materials research. Bruker's products assist pharmaceutical and biotech firms in studying protein structure abnormalities, the cause of many diseases. Chemical and raw material manufacturers use Bruker's systems in their research of materials for making such products as steel, semiconductors, and plastics. Bruker AXS sells its products in the Asia/Pacific, Europe, and the Americas through direct sales and distributors. The company is a subsidiary of Bruker Corporation. Sister subsidiary Bruker Daltonics manufactures mass spectrometers.

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