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The Queen's Medical Center was founded in 1859 by Queen Emma and King Kamehameha IV, Hawaiian royalty. With more than 530 beds and a staff of more than 1,200 physicians, the acute care facility is the largest private hospital in Hawaii and operates as a regional referral center. The not-for-profit medical center operates a cancer care and heart health center. Queen's Medical Center also offers specialty services such as behavioral health, diagnostics, orthopedics, physical therapy, women's health, and surgery. It also has community health care and laboratory services operations through an affiliated network of providers called The Queen's Health Systems.

The Reading Hospital and Medical Center does treat patients in Berks County, Pennsylvania and the surrounding area. The not-for-profit medical center provides acute care and rehabilitation programs, as well as behavioral and occupational health services. Specialty units include cancer, cardiovascular, weight management, diabetes, orthopedic, trauma, and women's health centers. The Reading Hospital and Medical Center was founded in 1868 as The Reading Dispensary. In addition to the main hospital, the center operates six other medical centers in nearby communities and imaging centers throughout its region. In total, its facilities have about 830 beds.

The University of Kansas Medical Center consists of educational facilities and the University of Kansas Hospital (KU Hospital). The hospital houses nearly 560 bed and 500 doctors. Its specialized services include emergency medicine, cardiology, cancer care, trauma care, and organ transplants, as well as stroke, prostate, and burn centers. KU Med's educational programs include a graduate school, as well as schools of medicine, nursing, and allied health. The medical center also houses health science research centers.

The University of Texas M. D. Anderson Cancer Center close to home. The center has been leading the fight against cancer for more than 65 years. Located on the Texas Medical Center campus, it is devoted exclusively to cancer patient care, research, education, and prevention. Part of the University of Texas System, the tertiary-care hospital helps some 95,000 patients annually with both inpatient and outpatient care. M.D. Anderson is a premier cancer research facility and discoveries in its labs are quickly put into practice with its patients. Additionally, the hospital is a teaching facility for medical professionals and researchers.

The Western Pennsylvania Hospital is a part of the West Penn Allegheny Health System. The 512-bed teaching hospital is affiliated with Clarion University, Indiana University of Pennsylvania, Pennsylvania State University, and Temple University. It offers specialized services such as emergency medicine, heart care, breast disease treatment, cancer treatment, orthopedics, and surgery (including microscopic surgery). Special facilities include an area burn center, cancer treatment center, and a hospice facility.

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