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Biocompatibles International operates under a concept of developing technologies that combine medical devices and therapeutic drugs. Several of its products, such as its DC Bead and LC Bead products, use proprietary polymer beads loaded with chemotherapy drugs to fight cancer; the beads are delivered to tumor locations during a minimally invasive procedure. The company has distribution agreements with AngioDynamics (in the US), Terumo Medical (Europe), and SciClone Pharmaceuticals (China). Device maker Medtronic uses the company's PC Technology platform in its Endeavor drug-eluting coronary stent. INVESCO holds a 25% stake in Biocompatibles.

Biocoral heals human bones with marine-life skeletons. The biomaterials company develops bone-graft substitutes derived from natural coral. The company's chief product, Biocoral, consists primarily of calcium carbonate and is very similar to bone tissue. It is used primarily by surgeons and doctors to treat and prevent fractures resulting from osteoporosis. Biocoral is also used for additional orthopedic, facial reconstruction, and oral surgery applications. The company's products are sold in Europe and Asia through its Biocoral France division. Biocoral plans to seek FDA approval to sell its products in the US.

Biodex Medical Systems aims to have a Rolodex overflowing with customers for its health care equipment. The company designs and manufactures a variety of products for the diagnostic radiology market, as well as equipment used for physical rehabilitation such as treadmills, elliptical cross-trainers, and balance testing equipment. Diagnostic supplies include tables, stretchers, and stools for medical imaging, as well as radiation shields, lung ventilation systems, and storage and dosing devices for nuclear medicine applications. Biodex Medical Systems' products are marketed through direct sales reps and international distributors. The company also offers technical support and clinical training for its equipment.

Biohit wants to be a hit in laboratories worldwide. The company manufactures fluid-handling products and diagnostic test systems for health care, research, and industrial laboratories worldwide. Its main liquid-handling products are electronic and mechanical pipette systems (or sample dispensers), as well as related accessories including controllers, stands, and disposable tips. Biohit also provides maintenance and user training services for its fluid-handling products. The company also develops and sells biological diagnostic products, including testing assays and instruments, used in the prevention and treatment of gastrointestinal ailments and other diseases. Biohit was founded in 1988.

BioHorizons manufactures and sells dental implants, or individual screw-in teeth, as an alternative to conventional dentures. The company also sells soft tissue regeneration products, called biologics, to help the gums grow back around the implant. For oral surgeons, BioHorizons offers tools and specialty instruments (including those by Hu-Friedy), as well as a software program, Virtual Implant Placement (VIP), to map treatment procedures. BioHorizons sells its products in more than 80 countries; one-third of sales come from outside the US. It's owned by private equity firm HealthpointCapital, but BioHorizons filed to go public in mid-2010.

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