NeuroMetrix, Inc., a medical device company, engages in the development and marketing of products that aid physicians in the assessment and treatment of diseases and injuries of peripheral nerves, and provide regional anesthesia and pain control. The company provides ADVANCE NCS/EMG system, a platform for the performance of traditional nerve conduction studies and invasive electromyography procedures; NC-stat System, a point-of-service neurodiagnostic solution for the performance of nerve conduction studies; and consumables and accessories for use with its neurodiagnostic equipment. The company is also developing the ASCEND platform, a proprietary neuro-electrical guidance system; NM101, for use in chronic spinal cord injury; and Andara Oscillating Frequency Stimulation device that is designed as a single use implant to enhance neurological recovery in patients with devastating loss of movement and sensation from acute spinal cord injuries. The company offers NC-stat System primarily to primary care and internal medicine physicians; and ADVANCE NCS/EMG System to neurologists, physical medicine and rehabilitation physicians, neurosurgeons, orthopedic and hand surgeons, and pain medicine physicians. It sells its products directly to physician offices, clinics, and hospitals in the United States and internationally. The company has a strategic alliance with Cyberkinetics. NeuroMetrix, Inc. was founded in 1996 and is headquartered in Waltham, Massachusetts.

New Splint brings some much-needed stability to orthopedic surgery patients.New Splint company is a supplier of orthopedic implants and surgical instruments, distributing products manufactured by companies such as Jarit, Stille, and Waldemar LINK, and providing customers with custom-made products as well. Its products are used in primary and revision surgical procedures on the spine, hands, and feet. Established in 1989, New Splint is now a part of the medical and scientific products division of Dublin, Ireland-based United Drug plc, which acquired it in 2002.

NMT Medical company develops implantable devices that treat defects in the walls of the heart's chambers. Its CardioSEAL and STARFlex implants close up holes in the heart, a condition suffered primarily by children.NMT Medical company markets CardioSEAL and STARFlex in the US, Canada, and Europe. A third device, BioSTAR, is a bioabsorbable implant that also corrects heart defects; it has been approved in Canada and Europe. NMT Medical acquired the exclusive rights to CardioSEAL from InnerVentions, a licensee of Children's Hospital Boston.

Novation isn't reinventing the wheels of healthcare, just greasing them a little.Novation company offers management consulting and supply chain services to hospitals and other health care facilities. Novation is one of the largest health care supply chain management firms in the nation, serving tens of thousands of health care organizations. It procures medical equipment and supplies, pharmaceuticals, laboratory equipment, food, and other products needed to keep the nation's health care facilities running. Novation is an affiliate of health care alliances VHA and University HealthSystem Consortium (UHC). Novation company was founded in 1998.

NuVasive company makes and markets medical devices for the surgical treatment of spinal disorders. NuVasive's products are primarily used in spinal fusion surgeries. Its minimally disruptive Maximum Access Surgery (MAS) platform enables surgeons to access the spine from the side of the body instead of from the front or back, and helps them avoid hitting nerves. NuVasive also offers the mesh, plates, screws, and biological implants (including allograft tissue) used with its MAS system.NuVasive company sells its FDA-approved products through a network of exclusive independent sales agencies, as well as NuVasive employees who target specific regions.

Oculus isn't the name of an all-seeing ancient Latin god or superhero, though it does use super-agents in its fight against the evil super-bug MRSA. Oculus Innovative Sciences works with proprietary platform technology Microcyn, a super-oxidized water-based solution designed to safely (i.e., without any known side effects) eliminate a wide range of annoying pathogens (including MRSA) attempting to infect patients with open wounds. Aside from use in wound care, the solution has potential applications for use in disinfectants and sterilization, as well as respiratory, dermatology, veterinary, and dental markets. Oculus' products are primarily sold through partnerships with distributors.

Ophthalmic Imaging Systems makes digital imaging products for use in ophthalmology. Its WinStation product line is used by retinal specialists and ophthalmologists to diagnose and treat diseases of the retina, including age-related macular degeneration. While the WinStation systems focus on imaging the back of the eye, the company's Digital Slit Lamp Imager emphasizes front-of-the-eye imaging. Ophthalmic Imaging Systems also sells image archiving, medical records management, and practice management software. Israel-based MediVision Medical Imaging holds more than 50% of the company and markets its products abroad. In 2008 MediVision agreed to acquire all of the company in an all-stock transaction.

Optiscan Imaging makes and develops microscopes and related technologies for examining tissue at the cellular and sub-cellular level. The company's original technology, Stratum, uses fluorescent imaging in the detection and treatment of skin cancer, which has reached epidemic proportions in the nation where Optiscan Imaging is headquartered -- Australia. Optiscan Imaging later worked on the development of a miniature scanner to be used in endoscopes, which led to a partnership with Pentax. Together they developed a confocal flexible endo-microscope product, launched in 2005. Optiscan has been in business since 1988.

OraSure is certain it can deliver results. The oral specimen kits and other diagnostic tests developed by OraSure Technologies are designed to detect drug use and certain infectious diseases, such as HIV. The company's OraSure products use oral specimens rather than traditional blood- or urine-based methods to test for HIV. Its Intercept line uses oral samples to test for marijuana, cocaine, opiates, PCP, and amphetamines. OraSure has also developed a rapid HIV blood diagnostic testing method. The company sells its products in the US and internationally through direct agents and independent distributors, primarily to public health clinics, hospitals, and doctors' offices.

Orthovita develops and sells materials for physicians to use as bone substitutes in reconstruction and replacement procedures. The company's products are designed to mimic natural bone characteristics and harden quicker than other available products. Orthovita's VITOSS product line, used for the repair of spinal and pelvic bone defects, accounts for about 60% of the company's sales. Its CORTOSS bone augmentation material -- expected to eventually become Orthovita's lead product -- received North American marketing approval from the FDA in 2009. Orthovita company already sells CORTOSS, which is used to repair vertebral compression fractures, in the EU and Australia.

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