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Ophthalmic Imaging Systems makes digital imaging products for use in ophthalmology. Its WinStation product line is used by retinal specialists and ophthalmologists to diagnose and treat diseases of the retina, including age-related macular degeneration. While the WinStation systems focus on imaging the back of the eye, the company's Digital Slit Lamp Imager emphasizes front-of-the-eye imaging. Ophthalmic Imaging Systems also sells image archiving, medical records management, and practice management software. Israel-based MediVision Medical Imaging holds more than 50% of the company and markets its products abroad. In 2008 MediVision agreed to acquire all of the company in an all-stock transaction.

Optiscan Imaging makes and develops microscopes and related technologies for examining tissue at the cellular and sub-cellular level. The company's original technology, Stratum, uses fluorescent imaging in the detection and treatment of skin cancer, which has reached epidemic proportions in the nation where Optiscan Imaging is headquartered -- Australia. Optiscan Imaging later worked on the development of a miniature scanner to be used in endoscopes, which led to a partnership with Pentax. Together they developed a confocal flexible endo-microscope product, launched in 2005. Optiscan has been in business since 1988.

OraSure is certain it can deliver results. The oral specimen kits and other diagnostic tests developed by OraSure Technologies are designed to detect drug use and certain infectious diseases, such as HIV. The company's OraSure products use oral specimens rather than traditional blood- or urine-based methods to test for HIV. Its Intercept line uses oral samples to test for marijuana, cocaine, opiates, PCP, and amphetamines. OraSure has also developed a rapid HIV blood diagnostic testing method. The company sells its products in the US and internationally through direct agents and independent distributors, primarily to public health clinics, hospitals, and doctors' offices.

Orthovita develops and sells materials for physicians to use as bone substitutes in reconstruction and replacement procedures. The company's products are designed to mimic natural bone characteristics and harden quicker than other available products. Orthovita's VITOSS product line, used for the repair of spinal and pelvic bone defects, accounts for about 60% of the company's sales. Its CORTOSS bone augmentation material -- expected to eventually become Orthovita's lead product -- received North American marketing approval from the FDA in 2009. Orthovita company already sells CORTOSS, which is used to repair vertebral compression fractures, in the EU and Australia.

OsteoTec do have a particular fondness for those body parts. OsteoTec distributes medical devices and implants in the UK, specializing in products used in hand, foot, and craniomaxillofacial surgical procedures. Products include finger and toe joints, wrist implants, tissue anchors, bone ties, and a cranial flap fixation system. The company's suppliers include Ascension Orthopedics, KMI Medical, and OsteoMed, and OsteoTec is also developing its own line of products.

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