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Q-Med seeks a smooth future, but thus far it still has a few wrinkles in its plans. The company develops and manufactures the high-tech goo Restylane dermatologists inject to fill in lines and creases in facial skin. Its Durolane product, also based on its non-animal sourced hyaluronic acids, is used as an injection to treat osteoarthritis of the knee. Its products are distributed in over 70 countries, but only Restylane has received FDA approval for use in the US. The Swedish company entered the US exchanges by buying up the shell of a public company in 2008.

Refocus Group is a medical device company that develops surgical treatments for human vision disorders. Therapeutic targets include presbyopia (commonly known as farsightedness), elevated blood pressure in the eye, and a certain form of glaucoma. Its most advanced device is the Scleral Spacing Procedure, which includes an incision handpiece, implants, and related surgical equipment, that could treat the previously mentioned vision disorders. Medcare Investment owns more than half of the firm.

ReGen Biologics, Inc. makes tissue implants and medical devices that are used to repair damaged or degenerating cartilage. ReGen's product line focuses on the repair and preservation of the meniscus, a piece of cartilage found in the knees. The company makes Menaflex, a collagen matrix product designed to halt deterioration, support natural regrowth of tissue, restore function, and reduce pain; the implant is approved for sale in Europe and the US (though its approval is under review in the US market). ReGen also makes the SharpShooter Tissue Repair System, a suturing device used in the Menaflex implantation procedure.

ResMed makes and distributes medical equipment used to diagnose and treat respiratory disorders that occur during sleep, such as sleep apnea. Most of its products treat obstructive sleep apnea (OSA), a condition in which a patient's air flow is periodically obstructed, causing multiple disruptions during sleep that lead to daytime sleepiness and possibly other conditions such as high blood pressure. Its products include air-flow generators, face masks, diagnostic products, and accessories. ResMed sells directly and through distributors worldwide to home health equipment dealers, sleep clinics, and hospitals.

REVA Medical Inc., founded in 1998, makes thin-walled heart and coronary artery stents from "bioresorbable" polymer materials using a "slide and lock" stent design. Its lead product candidate is the ReZolve coronary stent designed to restore blood flow and then resorb into the vessel. The company's products could also have applications in the orthopedic, neurological, and peripheral stent markets. Leading cardiac device maker Boston Scientific has partnered with REVA Medical and is helping the company develop its stents. The collaboration agreement also gives Boston Scientific the option to exclusively distribute REVA Medical's products if commercialized.

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