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Pennine Healthcare products may be disposable, but they're anything but dispensable. The company makes sterile, single use medical devices, manufacturing more than 50 million per year at its facilities in Derby. The disposable products are designed for applications in airway management (suction catheters, mucus extractors), gastroenterology (stomach tubes, bile bags), respiratory uses (filters, oxygen therapy), surgical suction (tubes and probes), and urology (various types of catheters). The firm also offers custom procedure packs for surgical procedures. Its products are sold by third-party distributors throughout the UK and in more than 70 countries.

Philips Healthcare makes it easier to get a look on the inside of things. Its parent company, Royal Philips Electronics, developed the first X-ray tube for medical use in 1918. Today, Philips Healthcare is a top global maker of medical imaging equipment, including X-ray, ultrasound, MR (magnetic resonance), and CT (computed tomography) scanners. The firm also makes patient monitors, resuscitation products, and data management systems, and it offers consulting, financing, training, and maintenance services. Philips Healthcare accounts for about 30% of its parent's sales and has operations in more than 60 countries.

PhotoMedex manufactures and markets dermatological treatments for skin disorders such as acne, psoriasis, and vitiligo (loss of skin pigmentation). Other products include gels and creams intended to promote skin rejuvenation and hair growth. PhotoMedex also develops lasers and fiber-optic equipment for dermatological and surgical applications. Its FDA-approved XTRAC excimer laser system is used for the treatment of psoriasis and eczema. The company operates throughout the US and internationally serving dermatologists, cosmetic surgeons, and spas.

Physio-Control (formerly Medtronic Emergency Response Systems) makes an integrated line of noninvasive emergency cardiac defibrillators and vital-sign assessment devices, as well as data management software. The company's LIFEPAK branded products are used both in and outside hospitals for the early detection and treatment of life-threatening events including trauma, heart attack, and the acute heart rhythm disturbances of bradycardia (slow heartbeat), tachycardia (rapid heartbeat), and ventricular fibrillation (chaotic heartbeat). Physio-Control is a unit of medical device maker Medtronic.

PLC Systems guards kidneys against ill effects of dehydration and toxic medicines. Its RenalGuard system, marketed in Europe, is a fluid balancing device that helps physicians monitor and maintain kidney fluid levels during medical imaging procedures. The company also developed the Heart Laser System, a carbon dioxide laser system that treats coronary artery disease; the system performs Transmyocardial Revascularization (or TMR) as an alternative to such conventional therapies as bypass surgery and balloon angioplasty. Novadaq is PLC Systems' exclusive distributor for its TMR business in the US; PLC agreed to sell the TMR business to Novadaq in 2010 to focus on development of RenalGuard for the US market.

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