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Oxford BioSignals Limited is in the business of developing products for the health care monitoring and diagnostic markets, as well as for industrial applications. The company uses technologies that stem from research done at the famous Oxford University, focusing on advanced signal processing and neural network technology. Products range from a brain wave analyzer used to detect sleep disorders in patients to a vibration analysis system that tests for and detects operational abnormalities in military jet engines. Rolls-Royce plc is a major shareholder of the company.

Palomar Medical Technologies' laser light show is more functional than flashy. Palomar makes laser and pulsed-light systems, along with related disposable products, for use in aesthetic procedures. The company's products include the EsteLux, StarLux, and MediLux systems. The systems, which are paired with a variety of handpieces, are used for skin resurfacing and acne treatments, hair removal, and treatment of leg veins, among other procedures. Additionally, Palomar's Q-YAG 5 laser removes tattoos and pigmented lesions. The firm markets its products through a direct sales force and distributors around the world.

Paradigm Medical Industries wants to keep those baby blues seeing clearly with its ophthalmic surgical and diagnostic equipment. Its FDA-approved products include its Blood Flow Analyzer, which measures pressure and blood flow within the eye and is used for early diagnosis of glaucoma, and a line of ultrasound biomicroscopes, which create high-resolution images of the eye that doctors use to diagnose and treat disease. The company has stopped development on its laser cataract removal system (branded Photon) because of lack of funds; it is focusing instead on marketing its diagnostic product line to ophthalmologists and optometrists.

Paragon Medical helps keep medical equipment safe and clean. The company designs and manufactures customized polymer and metal cases and trays used for surgical instrument storage and sterilization purposes, primarily for the original equipment manufacturer (OEM) market. Paragon also provides engineering, design, and manufacturing of surgical instruments and implantable medical device components for OEM customers. The company specializes in equipment and supplies for the orthopedic industry. Additional services include project management, consulting, sterilization validation, and inventory management. The company was founded in 1991 and has offices in North America, Europe, and Asia.

Pennine Healthcare products may be disposable, but they're anything but dispensable. The company makes sterile, single use medical devices, manufacturing more than 50 million per year at its facilities in Derby. The disposable products are designed for applications in airway management (suction catheters, mucus extractors), gastroenterology (stomach tubes, bile bags), respiratory uses (filters, oxygen therapy), surgical suction (tubes and probes), and urology (various types of catheters). The firm also offers custom procedure packs for surgical procedures. Its products are sold by third-party distributors throughout the UK and in more than 70 countries.

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