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The SmartPill is a medical device development company that thinks small. Really small. A patient swallows a SmartPill capsule-based device which then tracks its progression through the digestive tract, including location, pressure, and the time it takes to pass through the intestines. Data measurements are transmitted via radio frequency and recorded by an external receiver for several days. Designed as a less invasive alternative to endoscopic methods that often require anesthesia, the SmartPill can help physicians diagnose and treat gastrointestinal disorders on an outpatient basis.

The Spectranetics Corporation takes its mission to heart: The company develops, markets, and distributes an excimer laser system that is used to treat various coronary and vascular conditions. Its CVX-300 laser unit and fiber-optic delivery devices (disposable catheters and sheaths) remove partial or total arterial blockages caused by plaque buildup; the laser system can also be used to remove lead wires from pacemakers and implantable defibrillators. The company's customers include major cardiac catheterization labs and hospitals in the US. Subsidiary Spectranetics International sells the company's products abroad, primarily in Europe and the Middle East.

Theragenics' seeds, sold under the names TheraSeed and I-Seed, are tiny rice-sized radioactive implants used to fight prostate cancer. The devices (known more generally as brachytherapy seeds) are a common treatment for early-stage prostate cancer; they release radiation within the tumor that kills cancerous cells with minimal damage to surrounding healthy tissue. Theragenics sells the devices directly to hospitals and through distribution agreements throughout the US and in Europe. In addition to its brachytherapy business, Theragenics' surgical products unit makes vascular and wound care products, including sutures and guidewires.

ThermoGenesis Corp. makes equipment that harvests, freezes, and thaws stem cells and other blood components taken from adult sources like umbilical cord blood, placentas, and bone marrow. Its core products include the AutoXpress System (AXP), a medical device that retrieves stem cells from cord blood; and the BioArchive System, which freezes and stores stem cells harvested from such blood. Other products include Res-Q, which processes stems cells from bone marrow, and the plasma storage product ThermoLine. Founded in 1986, the company sells its products to cord blood banks, stem cell researchers, and clinical laboratories around the world.

TherOx is a medical device company that developed the SuperSaturated Oxygen (SSO2) Therapy System to prevent muscle tissue death following a heart attack. The SSO2 Therapy System mixes oxygen and saline with the patient's blood and pumps it back through the coronary artery to restore blood flow and reduce the amount of heart muscle tissue that dies after a person goes into cardiac arrest. The SSO2 System has not been FDA-approved; TherOx has conducted two studies involving 570 patients and hopes to be able to market the product in mid-2009.

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