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When it comes to surgical implants, RTI Biologics recommends the natural alternative. The firm develops products made from human and animal tissue that are used in orthopedic, dental, and other surgeries to repair fractures, spinal disorders, sports injuries, breast reconstruction, and other procedures. Using its BioCleanse and Tutoplast processes, the company sterilizes tissue -- including bone, tendons, and skin -- that is then used in surgeries. RTI Biologics sells its allografts (made from human tissue) and xenografts (made from animals) in the US and more than 30 countries. Its direct sales force targets the sports medicine and general orthopedic markets.

Safety Syringes wants to ensure that when you're getting needled, it's with deliberate intention. The company manufactures devices designed to prevent accidental needle pricks. Safety Syringe's products include UltraSafe Needle Guards, which attach to prefilled glass syringes, and UltraSafe Passive Needle Guards, in which a safety guard locks into place upon completion of shot delivery. The company develops products used for medical and dental drug delivery, vaccines, blood collection, and intravenous catheters. Customers for pre-filled syringes include Amgen, Merck, Roche, and Pfizer. The company was founded in 1990 and primarily operates in North America, Europe, and Asia.

Salient Surgical Technologies (formerly TissueLink Medical) tries to keep blood loss to a minimum. The company develops, manufactures, and markets medical devices using its proprietary TRANSCOLLATION, a technology that combines radiofrequency (RF) energy and saline to reduce or stop bleeding in surgery. The thermal energy is delivered via Salient's main product, AQUAMANTYS, which consists of an RF pump generator and disposable handheld sealer tools that permanently seal blood vessels, soft tissue, and bone. Salient markets the system in the US, Europe, and Asia primarily for use in orthopedic hip and knee reconstruction surgeries and certain spinal fusion procedures.

Sangui BioTech International focuses on the fluid of life -- blood. The firm specializes in developing oxygen-carrying agents to treat blocked arteries, anemia, or acute blood loss through its Sangui GmbH subsidiary. Also in the pipeline at Sangui is an implantable blood glucose monitor for diabetics. Other products include Pure Moisture, an anti-aging skin care product; HemO2Spray, a spray-on wound treatment; and Chitoskin, a wound dressing that is said to facilitate rapid healing of wounds. Professor Wolfgang K. Barnikol founded the company in Germany in 1995.

"Sterile" is the watchword at Sartorius Stedim Biotech (SSB). The company makes and supplies equipment used in the medical and biopharmaceutical industries for filtration, fluid management, fermentation, purification, and laboratory applications. Products include sterilized, disposable bags, systems that freeze or thaw pharmaceutical components, as well as systems for the sterile transfer of liquids or solids. SSB sells its products to the pharmaceutical, chemical and food and beverage industries, as well as research and educational institutes around the globe. Formerly called Stedim, the firm changed its name in 2007 when it was acquired with German lab equipment maker Sartorius.

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