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Novadaq Technologies produces medical imaging devices that are used during surgeries. Its SPY Intra-Operative Imaging System uses the fluorescent properties of indocyanine green dye to give surgeons new views of the arteries and grafts they're working on during coronary or reconstruction surgery. The company's PINPOINT imaging system is used to identify healthy and cancerous tissues during lung surgeries. Novadaq is also developing the OPTTX System to diagnose and treat age-related macular degeneration (AMD) -- it combines two functions, imaging and cauterizing, into one device.

NxStage Medical is giving some life back to those needing dialysis to treat acute kidney failure and end-stage renal disease. The medical device company's primary product, System One, is a portable hemodialysis machine, which can be used by patients at home or by professionals in a hospital setting. The FDA-approved device is also marketed to hospitals for critical care and to dialysis clinics that want to create or expand their services to home-based patients. Typically, customers rent the System One equipment, but its largest customer, DaVita, has chosen to purchase. NxStage Medical's subsidiary, Medisystems, supplies customers with disposable blood tubing and needles.

Oncology Services International (OSI) sells, installs, and provides radiation therapy equipment and related services, including medical linear accelerators, GE Computed Tomographic Scanners, radiation therapy simulators, and accessories worldwide. The company was formed following the merger between Accelinear and Linac Systems in 2003. OSI has facilities in California, Georgia, New Jersey, Ohio, and Texas.

Optos has opted to provide improved imaging tools to eye doctors. The company is a manufacturer of digital diagnostic imaging equipment used by ophthalmologists and other eye care professionals in the detection and management of eye disease. The company's Optomap laser ophthalmoscopes are used by ophthalmologists to perform precision retinal examinations. Its tools are used to detect ailments such as retinal detachments, age-related macular degeneration, and glaucoma and are marketed to physicians in Europe and North America. Optos was founded in 1992 by executive vice chairman and engineer Douglas Anderson after his son's retinal disorder was overlooked by eye doctors.

Organogenesis has the skinny on replacement tissue. Flagship product Apligraf is a human skin substitute approved to treat diabetic foot ulcers and venous leg ulcers caused by poor circulation. Rejection-resistant Apligraf is bio-engineered using living skin cells and has been used to treat chronic open wounds in some 250,000 patients; the company is developing a next-generation version of the material (using its VCT technology) using all human components. In addition to Apligraf, Organogenesis offers a line of biomaterials used in a range of surgical procedures to seal or reconstruct soft tissue, and it also develops regenerative technologies in the area of cosmetic skin rejuvenation.

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