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Nobel Biocare can fix you up with restorative dental implants, crowns, or bridgework when your natural teeth fail you. The company also makes dental prosthetics (dentures) and has products to plug up any small gaps between teeth for purely aesthetic reasons. Its brands include Brånemark, NobelDirect, and Procera (which it rebranded as NobelProcera in 2009). Based in Switzerland, the company has production facilities in Sweden, US, Japan, and Israel. It has a direct sales presence in more than 35 countries and also sells through distributors, giving it a global reach.

NIMS(Non-Invasive Monitoring Systems, Inc.) has developed a moving bed-style device that is intended to improve circulation and joint mobility, and possibly to relieve minor aches and pains. Originally tagged as AT-101, the device was sold in Japan and the US until the FDA required the company to get regulatory approval for it. NIMS halted sales and marketing efforts on AT-101 and is seeking FDA approval for a similar but less costly device known as the Exer-Rest, intended for home and clinic use.

Noninvasive Medical Technologies helps physicians provide gentler health care. The company manufactures noninvasive hemodynamic monitors that measure blood flow, heart rate, stroke volume, and cardiac output. Its IQ2 is used to assess and evaluate cardiac function. The ZOE device determines if a patient is retaining fluids or is dehydrated without drawing blood. By quickly assessing fluid status, doctors can better treat those at risk for severe or recurring dehydration such as hypertension and heart failure patients and athletes. The company also sells ICG sensors (to obtain hemodynamic data) and electrodes used with its devices. NMT has a supplier agreement with Royal Philips Electronic for its ZOE monitor.

Novadaq Technologies produces medical imaging devices that are used during surgeries. Its SPY Intra-Operative Imaging System uses the fluorescent properties of indocyanine green dye to give surgeons new views of the arteries and grafts they're working on during coronary or reconstruction surgery. The company's PINPOINT imaging system is used to identify healthy and cancerous tissues during lung surgeries. Novadaq is also developing the OPTTX System to diagnose and treat age-related macular degeneration (AMD) -- it combines two functions, imaging and cauterizing, into one device.

NxStage Medical is giving some life back to those needing dialysis to treat acute kidney failure and end-stage renal disease. The medical device company's primary product, System One, is a portable hemodialysis machine, which can be used by patients at home or by professionals in a hospital setting. The FDA-approved device is also marketed to hospitals for critical care and to dialysis clinics that want to create or expand their services to home-based patients. Typically, customers rent the System One equipment, but its largest customer, DaVita, has chosen to purchase. NxStage Medical's subsidiary, Medisystems, supplies customers with disposable blood tubing and needles.

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