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Sinai Health System provides medical care for the residents of West Side of Chicago. The system is comprised of its flagship Mount Sinai Hospital (which houses about 430 beds), Schwab Rehabilitation Hospital, and the Sinai Children's Hospital. The health system's Sinai Medical Group provides primary and specialty care through a range of clinics in the area. The Sinai Community Institute offers health, wellness, and educational programs for all ages, ranging from prenatal care to parenting education and employment services for senior citizens. Mount Sinai Hospital is affiliated with the Rosalind Franklin University of Medicine and Science in Chicago.

Sinai-Grace Hospital hopes to provide health care to grateful Detroit residents. The acute care medical center has about 400 beds and 800 physicians providing a variety of emergency, general, specialty, and outpatient services. Specialist programs include cancer care, cardiology, gastroenterology, orthopedics, rehabilitation, women's and children's services, and reconstructive surgeries. Sinai-Grace provides training to medical students through an affiliation with Wayne State University. The hospital is part of the Detroit Medical Center network.

Sisters opened a private hospital, establishing the foundation for what would eventually be the Sisters of Charity of Leavenworth Health System (SCLHS). Today, the not-for-profit health care organization operates nine hospitals and four clinics throughout California, Colorado, Kansas, and Montana, with a total of more than 2,000 beds. Its facilities include acute care, extended care, and rehabilitation services. True to its name, the organization's facilities continue to provide health services to low-income and uninsured people.

Sisters of Mercy provides a range of health care and social services through its network of facilities and service organizations. The organization operates more than two dozen acute care hospitals (including three specialty heart hospitals) with some 4,000 licensed beds in seven states throughout the South and Midwest. Its hospital groups include facilities for nursing homes, medical practices, and outpatient centers. Sisters of Mercy Health System also runs health outreach organizations in Louisiana, Mississippi, and Texas.

Sisters of St. Francis Health Services operates eight acute care medical centers (some with multiple campuses) in central and northern Indiana and south suburban Chicago. The hospital facilities house about 3,500 beds; in addition to inpatient acute care services, they operate numerous outpatient facilities and medical practices within their local service areas. Other subsidiaries supply health insurance to Indiana residents; perform clinical laboratory tests, offer home health care services, and provide construction and IT services to the systems' facilities and other clients. The firm is a member of group purchasing organization Consorta. It was founded by the Sisters of St. Francis of Perpetual Adoration.

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