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The drug development industry has come along way in the last two decades. In the 1980s and early 1990s, when the focus was on cost-savings and capacity management, contract research organizations (CROs) were used primarily as spillover capacity. The work was done and often done well, but our relationship with our pharmaceutical clients was tactical, and CRO growth rates and profitability were volatile. From roughly 2000 to 2005, biotechnology and specialty pharmaceutical companies began to use CROs more strategically, which stabilized demand and improved the performance and return on investment of CROs.

Covance, with headquarters in Princeton, New Jersey, is one of the world’s largest and most comprehensive drug development services companies, with annual revenues greater than $1.8 billion, employees in more than 60 countries, and more than 10,000 employees worldwide The drug development industry has come along way in the last two decades. In the 1980s and early 1990s, when the focus was on cost-savings and capacity management, contract research organizations (CROs) were used primarily as spillover capacity. The work was done and often done well, but our relationship with our pharmaceutical clients was tactical, and CRO growth rates and profitability were volatile. From roughly 2000 to 2005, biotechnology and specialty pharmaceutical companies began to use CROs more strategically, which stabilized demand and improved the performance and return on investment of CROs.

CytoSorbents Inc. is located in Monmouth Junction, New Jersey. CytoSorbents Inc., formerly known as MedaSorb Technologies, Inc., is the operating company of MedaSorb Technologies Corporation (www.medasorb.com). CytoSorbents Inc. is a medical device company that has developed a new adsorbent platform technology for removal of toxins from blood and physiologic fluids. CytoSorbent's products are comprised of porous, adsorbent polymer beads that target molecules up to 50,000 Daltons, such as pro-inflammatory and anti- inflammatory cytokines i.e. IL-1, IL-6, TNF and Il-10, which are associated with sepsis. These cytokines are believed to be largely untouched by current blood purification techniques, including state of the art dialysis technology. Our near term focus is achieving regulatory approval of CytoSorb™ which is expected to be used for the treatment of sepsis, cardiopulmonary bypass surgery, organ donation and drug overdoses, all of which have a common theme, blood borne toxins.

diaDexus is a diagnostics company, located in South San Francisco, California, focusing on the development and commercialization of patent-protected in vitro diagnostic products addressing unmet needs in cardiovascular disease. diaDexus was formed in 1997 as a joint venture between SmithKline Beecham (now GlaxoSmithKline) and Incyte; upon formation, GSK granted diaDexus an exclusive license to certain diagnostic intellectual property, including the PLAC Test for Lp-PLA2. The PLAC Test is the only blood test cleared by the FDA to assess risk for coronary heart disease and ischemic stroke associated with atherosclerosis.

Diagnostic Laboratory Services (DLS) provides clinical laboratory and employee drug screening services in Hawaii and other Pacific islands. The company's toxicology department provides drug testing services for private companies, federal and state agencies, and health care providers. DLS' microbiology department provides infectious disease testing services. The company also provides provides diagnostic pathology lab services, including biopsy and pap smear analysis, through affiliate Hawaii Pathology Laboratory. DLS operates satellite locations throughout the Hawaiian Islands, Guam, and Saipan and has hospital-based laboratories including one at the affiliated Queen's Medical Center in Honolulu.

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