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CryoCor has found that being cold-hearted can be helpful sometimes. The company makes a minimally-invasive disposable catheter and cooling console to treat common cardiac arrhythmias (heart rhythm disorders) known as atrial fibrillation and atrial flutter. Unlike commonly used heat-based cardiac ablation, its cryoablation system inserts a catheter into a blood vessel connected with the heart and uses extreme cold to destroy targeted cells and help the heart function normally. The cryoablation system is marketed for certain indications in the US and Europe. CryoCor is a part of the cardiac rhythm management division of parent Boston Scientific.

CryoLife preserves lives by conserving the tissues that sustain it. The company takes human heart valves and blood vessels from deceased volunteer donors, processes them, and stores them in liquid nitrogen freezers (a process called cryopreservation). It then ships them to surgeons nationwide, who implant them during cardiac and vascular repair procedures. For some preserved tissue, the company uses its proprietary SynerGraft technology, which reduces the presence of donor cells and makes the tissue more compatible with the recipient. CryoLife also develops implantable biomaterials, including BioGlue, an adhesive used to seal internal surgical wounds.

CV Laser Pty Ltd T/as CustomVisTM is an innovative company in the laser vision correction industry, with a focus on "custom surgery." The company's flagship product, the PULZARTM Z1 is a solid state refractive laser that is designed specifically for custom surgery, permitting an accurate approach to correcting both standard and non-standard vision disorders. The PULZARTM Z1 system uses a patented solid-state technology, permitting surgeons to treat more patients, with greater accuracy, and also to treat patients that other technologies may be unable to treat.

Cutera has a handle on hairy situations and a firm plan for flabby faces. The firm makes lasers for medical and aesthetic use in doctors' offices and spas. Its FDA-approved devices are marketed under the names CoolGlide, Solera, and Xeo and are used for hair removal and treatments to reduce pigmented lesions (age and sun spots), wrinkles, and veins. Its Titan line of products uses deep tissue heating to firm up saggy skin. The company markets its products through a direct sales force and a distributor (PSS World Medical) in the US and relies on a small sales group and distributors in more than 30 other countries.

Cyberonics makes the first medical device to be cleared by the FDA for treating epilepsy. The company's VNS Therapy System is a pacemaker-like device implanted under the collarbone with a lead attached to the vagus nerve in the neck. The device delivers intermittent signals to the brain, dubbed vagus nerve stimulation (VNS), to control epileptic seizures. The signals can be programmed by a physician using a computer, and patients can stop or start signals with a hand-held magnet. The VNS system is also used for treatment-resistant depression, and it is being studied for conditions such as bulimia and Alzheimer's disease. In addition to the US, Cyberonics markets the system in about 70 countries around the globe.

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