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ICU Medical, Inc. engages in the development, manufacture, and sale of disposable medical connection systems for use in vascular therapy applications in the United States and internationally. Its disposable medical devices protect patients from catheter related bloodstream infections, and healthcare workers from exposure to diseases through accidental needle sticks or hazardous drugs. The company offers I.V. therapy lines consisting of a tube running from a bottle or plastic bag containing an I.V. solution to a catheter inserted in a patient’s vein for use in hospitals and ambulatory clinics; CLAVE product, a needleless I.V. connection device, which could be used with conventional peripheral or central vascular access systems for venous and arterial applications; custom infusion sets, custom oncology sets, and custom critical care sets; and CLC2000, a one piece swabbable connector used to connect I.V. lines to catheters to prevent the back-flow of blood into the catheter. It also provides critical care products that monitor vital signs and specific physiological functions of key organ systems, including pressure monitoring devices, blood sampling systems, angiography kits, sensory catheters, pulmonary artery thermodilution catheters, and multilumen central venous catheters. In addition, the company provides TEGO for use in dialysis; a line of oncology products, including Spiros male luer connector device; the Genie vial access device; the Orbit 90 diabetes set; and custom I.V. sets and ancillary products for oncology therapy. ICU Medical, Inc. sells its products through I.V. product manufacturers and independent distributors, as well as directly to the end users. ICU Medical, Inc. was founded in 1984 and is headquartered in San Clemente, California.

IOP, Inc., headquartered in Costa Mesa, California, is an innovation-driven, medical technology company, providing specialty ophthalmic surgical devices worldwide. IOP, Inc. develops, commercializes and distributes a wide range of technologies to the oculoplastic, glaucoma and cornea subspecialty markets. IOP, Inc., founded in 1988, is focused on leading-edge surgical technologies. IOP, Inc. has leadership positions with bioimplants and devices for ophthalmic plastic and reconstructive surgeries; glaucoma implant drainage technology; and bioimplants for a wide range of ophthalmic surgical applications.Through intimate relationships with key clinical and market leaders, IOP, Inc. has an established and focused technology-development pipeline. Innovative Ophthalmic Products believes it will lead to differentiated, unique technologies that will satisfy unmet surgeon and patient demands. IOP, Inc. uses a variety of innovative methods and strategic collaborations to develop and deliver technologies offering solutions. Innovative Ophthalmic Products has formed and currently maintains strategic alliances with OKTO Ophtho, Tutogen Medical, Inc., Molteno® Ophthalmic Ltd., Advanced Meditech International Inc. and Osmed GbH.

Integra LifeSciences Holdings Corporation develops, manufactures, and markets surgical implants and medical instruments for neurosurgery, extremity reconstruction, orthopedics, and general surgery primarily in the United States, Europe, and the Asia Pacific. Its orthopedics product portfolio comprises dermal regeneration and engineered wound dressings to treat the chronic wounds; nerve and tendon for the peripheral nerve repair and protection; bone and joint fixation devices and instruments for upper and lower extremity reconstruction; and bone graft substitutes for extremity reconstruction. The company’s spine and orthobiologics product portfolio includes spinal fusion devices for fusing two vertebrae; supplemental fixation systems for cervical procedures; interbody/vertebral body replacement devices to hold the graft in place to ensure a fusion; orthobiologic products for the repair and regeneration of bone in spinal and trauma surgery; and minimally invasive spine products. Integra’s neurosciences product portfolio includes duraplasty products for managing dural defects; tissue ablation equipment for the ablation of unwanted tissue; cerebral spinal fluid management devices for managing the intracranial pressure of a neuro-compromised patient; cranial stabilization equipment for fixing the head in an orientation determined by the surgeon; and intracranial monitoring equipment for monitoring intracranial pressure and metabolic activity. Its medical instruments product portfolio comprises room instrumentation and surgical lighting; and hand-held surgical instruments for the surgical, dental, podiatry, and animal health markets. Integra LifeSciences Holdings Corporation sells its products directly through various sales forces and other distribution channels. Integra was founded in 1989 and is headquartered in Plainsboro, New Jersey.

ISG was founded in 1975 as Suburban Ostomy; today it is a subsidiary of Invacare. Invacare Supply Group (ISG) makes sure that Invacare's distribution wheels are always greased. ISG, a subsidiary of medical equipment maker Invacare Corporation, is a national wholesale distributor of thousands of medical equipment and supply items, including Invacare-brand wheelchairs and products for orthopedics, diabetes, wound care, ostomy, and urological ailments. Through six regional distribution centers in the US, ISG serves customers including managed care companies, pharmacies, home medical equipment providers, and national home-care chain operators.

IVAX Diagnostics, Inc. is headquartered in Miami, Florida and develops, manufactures and markets proprietary diagnostic reagents, instrumentation and software worldwide through its three subsidiaries; Diamedix Corporation, Delta Biologicals S.r.l. and ImmunoVision, Inc. IVAX Diagnostics, Inc. was created as a result of the merger on March 14, 2001 between b2bstores.com, Inc. and the diagnostic business subsidiary within IVAX Corporation. On January 26, 2006 , IVAX Corporation was merged into a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd. (Teva). As a result of this merger, Teva, indirectly through its IVAX Corporation subsidiary, owned approximately 72% of IVAX Diagnostics. On September 2, 2008 , a group controlled by two experienced and well-known international medical diagnostics and pharmaceutical industry entrepreneurs, Paul Kennedy and Patrice Debregeas, purchased all of the shares of IVAX Diagnostics' common stock owned by Teva and, accordingly, collectively owns approximately 72% of IVAX Diagnostics. IVAX Diagnostics' common stock trades under the ticker symbol IVD on the American Stock Exchange.

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