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Arthritis Foundation (AF) wants the country's aches to go away. The not-for-profit organization funds research, advocacy, and support services for various kinds of arthritis and related diseases. Arthritis Foundation has about 45 chapters in 33 states and offers programs and services including aquatic programs, information about treatment breakthroughs, exercise tips for people with the disease, and pain management information. AF raises money through The Arthritis Walk, Jingle Bell Walk/Run, and Joints in Motion, a program that trains participants to run a marathon or hike a tough trail and take part in a fund raising event. Arthritis Foundation was founded in 1948.

The American Society for the Prevention of Cruelty to Animals (ASPCA) was the first humane society to be established in North America and is, today, one of the largest in the world. ASPCA was founded by Henry Bergh in 1866 on the belief that animals are entitled to kind and respectful treatment at the hands of humans, and must be protected under the law. ASPCA watches out for Fidos, Fluffies, and other furry friends all across the country. The ASPCA (American Society for the Prevention of Cruelty to Animals) is a not-for-profit organization dedicated to promoting the humane treatment of non-humans. ASPCA engages in education, public awareness, and government advocacy effort, and it supports the work of independent humane societies throughout the US. ASPCA provides medical services and animal placement from facilities in New York City. About two-thirds of the ASPCA's revenue comes from contributions, grants, and dues from more than 1 million members and donors. ASPCA was established in 1866 by Henry Bergh.

Barnardo’s believes in children, no matter who they are. Barnardo’s vision today is that the lives of all children and young people should be free from poverty, abuse and discrimination. Barnardo’s believe in the abused, the vulnerable, the forgotten and the neglected. Barnardo's pledge to support them, stand up for them and bring out the best in each and every child. With a long history in the UK, Barnardo's is dedicated to supporting children and young people in need throughout England, Northern Ireland, Scotland, and Wales. The not-for-profit organization helps some 110,000 children and their families suffering from problems such as abuse, poverty, homelessness, and discrimination; another major focus is helping children who are the major caregivers in their families. Barnardo's also runs about 330 shops across the UK, as well as an online store in order to raise funds for its projects. Barnardo's was formed in 1867 to provide for orphans and other destitute children.

Big Brothers Big Sisters is the oldest, largest and most effective youth mentoring organization in the United States. Big Brothers Big Sisters of America have been the leader in one-to-one youth service for more than a century, developing positive relationships that have a direct and lasting impact on the lives of young people. Big Brothers Big Sisters mentors children, ages 6 through 18, in communities across the country - including yours. Big Brothers Big Sisters of America network of some 400 local agencies serves more than 250,000 youths. Big Brothers Big Sisters of America pairs at-risk youth with adults for casual interactions like going to movies, sporting events, parks, and just being together. Adults, or "Bigs," are interviewed, screened, trained, and approved by the parent or guardian of the "Littles." Agency staff makes matches and a caseworker stays in touch with the pair to make sure everything works well. Big Brothers Big Sisters of America is funded by federal, state, and local government, as well as individuals, foundations, and companies.

Born Free USA (formerly Animal Protection Institute) advocates the protection of animals from exploitation and cruelty. The not-for-profit group employs public education, governmental lobbying, litigation, and grassroots organizing to prevent the keeping of exotic pets, protect animals used in entertainment, control the international wildlife trade, and abolish trapping and the use of fur in fashion. Born Free USA United with Animal Protection Institute primate sanctuary in Texas cares for animals rescued from labs, roadside zoos, and private ownership. Founded in 1968, API merged with Born Free USA (the US arm of the UK's Born Free Foundation, formed by the stars of the film Born Free) to form Born Free USA United with Animal Protection Institute in 2007.

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