Sree Leela made her debut in 2019 with Kiss for which she won SIIMA Awards Best Female Debut – Kannada.

Sree Leela was born on 14 June 2001 into a Telugu family in the United States, and was brought up in Bangalore, Karnataka.

Leela mother Swarnalatha is a gynaecologist based in Bangalore. Swarnalatha was married to industrialist Surapaneni Subhakara Rao, and Leela was born to Swarnalatha after their separation.

Leela began her training in Bharatanatyam dance since she was a child. She aspires to become a doctor, and is in the final year of MBBS as of 2021.

In February 2022, Leela adopted two disabled children.

Director A. P. Arjun who came across Leela's pictures taken by cinematographer Bhuvan Gowda on social media, cast her in his directorial film Kiss (2019).

Leela said that she chose to start her career in Kannada films as she grew up in Bangalore, despite having contacts in Telugu film industry.

Sree Leela began shooting for her debut film Kiss in 2017 while she was in the first year of her pre-university course.

In 2021, Leela was cast in romantic musical film Pelli SandaD, marking her debut in Telugu cinema.