Celsis International plc company was founded in 1992. Celsis International is all about playing it safe. Through the company's Product Group, it makes rapid diagnostic and monitoring systems used to detect and measure microbial contamination in consumer products and food. Its RapidScreen assays are used by makers of personal care goods, cosmetics, OTC drugs, and a variety of beverages. CellScan Innovate is used by dairy producers. The division, which accounts for little more than half of Celsis International's sales, counts among its customers Dow Corning and Gillette. Celsis Laboratory Group performs quality testing for the cosmetics, drug, and chemicals industries.

Fluidigm Corporation was founded as Mycometrix Corporation in 1999 and changed its name to Fluidigm Corporation in June 2001. The company is based in San Francisco, California. Fluidigm Corporation develops and distributes systems based on the properties of integrated fluidic circuits to control precisely fluids on a nano volume scale. The company's product line includes the TOPAZ system, which is used for protein crystallization; and the BioMark system, which is used for genetic analysis.

Mera Pharmaceuticals, Inc. was founded in 1983 and is based in Kailua-Kona, Hawaii. Mera Pharmaceuticals, Inc. primarily develops and commercializes natural products derived principally from microalgae using its patented photobioreactor technology known as the Mera Growth Module. Mera Pharmaceuticals company's product line consists of ASTAFACTOR, a nutraceutical and source of natural astaxanthin; and SALMON ESSENTIALS, a combination of astaxanthin and omega-3 fatty acids. It markets its products to retail outlets in Hawaii through distribution arrangements with established companies.

Don and Lucy Hillestad founded Hillestad Pharmaceuticals USA, Inc. in 1959. Hillestad Pharmaceuticals USA goes natural, producing vitamin, mineral, protein, and herb products from all-natural sources. It also makes prescription and nonprescription vitamin products for dialysis patients under the Dialyvite and Hill*Vite names. In addition, Hillestad offers private-label manufacturing of tablets, powders, cremes, lotions, and liquids for doctors and pharmacies, health food stores, and various national and international companies.

MPI Research was founded in 1962. MPI Research helps drug developers answer a crucial question: Is it safe? The contract research organization (CRO) specializes in providing pre-clinical research services to pharmaceutical, medical device, chemical, and agricultural development companies, as well as regulatory and other government agencies. Its toxicology testing services investigate and determine the safety and dosage levels of substances being considered for use in drugs, pesticides, petrochemicals, and food additives. MPI Research also offers contract bioanalytical and pharmacology services.

NitroMed, Inc. company has developed a technique to enhance nitric oxide and add it to drugs to improve their efficiency. Nitric oxide is formed in the body and plays a role in relaxing blood vessels, making it harder for blood platelets to stick to blood vessel walls, and thereby reducing the obstructions that lead to stroke. Its sole product, BiDil, has FDA approval and is specifically indicated for heart disease in self-identified African-Americans, a group that suffers from the disease at a higher rate than other ethnicities. NitroMed was acquired by health care investment group Deerfield Capital Management in 2009.

Synbiotics is concerned with the conditions of cats, cows, canines, and other critters. The company provides diagnostic products for the animal health care industry worldwide, through facilities in the US and France. Its canine reproduction services division trains vets in canine reproductive services, including artificial insemination, and runs the Canine Freezing Center Network, which operates what Synbiotics says is the largest bank of frozen canine semen in the world. Synbiotics company also develops and markets test kits for animal parasites, pregnancy, viruses, and other diseases and conditions in the animal kingdom. Its test for bird flu, the FluDetect Avian Influenza Type A antigen kit, is sold globally.

Marligen Biosciences is where researchers go again and again for testing products and services. The company makes nucleic acid purification systems, genetic analysis assays, and other genomics research supplies. Its nucleic acid purification systems include rapid plasma purification systems which are used for isolation DNA so it can mapped, cloned, amplified, labeled, and sequenced. Its genetic analysis assays are sold under the Signet brand name and can screen for certain classes of DNA or be tailored to the researchers needs. Marlingen was acquired by another genetic services provider, OriGene, in 2009.

ActivX Biosciences figures that the more you know about protein kinases, the easier it will be to inhibit them. That's the basis of its main product: a platform to profile protein kinases -- enzymes that regulate cell's signaling pathways. Its KiNativ platform has been launched for use by pharmaceutical and biotechnology companies as they develop the kinase inhibitors expected to make drug breakthroughs. The company also has its own pipeline of drug candidates in development, including one in trials for the treatment of Type-2 diabetes. Japanese drugmaker Kyorin Pharmaceutical, with whom ActivX had collaborated since 2002, bought the company in 2005 for $21 million.

Opexa Therapeutics was founded in 2003 and is based in The Woodlands, Texas. Opexa Therapeutics, Inc. operates as a biopharmaceutical company, developing autologous cellular therapies with the potential to treat major illnesses, including multiple sclerosis (MS) and diabetes. These therapies are based on Opexa's proprietary T-cell and adult stem cell technologies. The company's products include a T-cell therapeutic vaccine, Tovaxin, which is in clinical development for the treatment of MS. The adult stem cell technology is in the preclinical development stage. The company was formerly known as PharmaFrontiers Corp. and changed its name to Opexa Therapeutics, Inc. in June 2006.

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