Alfacell Corporation was founded in 1981 and is headquartered in Somerset, New Jersey. Alfacell Corporation, a biopharmaceutical company, primarily engages in the discovery and development of a class of therapeutic drugs for the treatment of cancer and other pathological conditions. Its proprietary drug discovery and development program consists of therapeutics developed from amphibian ribonucleases. The company's lead drug product candidate, ONCONASE is evaluated in human clinical trials for the treatment of various forms of cancer. It also focuses on new drug application for unresectable malignant mesothelioma. In addition, the company completed a Phase I clinical trial for the treatment of non-small cell lung cancer.

Momenta Pharmaceuticals was founded in 2001 and is based in Cambridge, Massachusetts. Momenta Pharmaceuticals, Inc., a biotechnology company, specializes in the structural analysis of complex mixture drugs. The company applies its technology for the development of generic versions of complex drug products, as well as for the discovery and development of novel drugs. Its product candidates include M-Enoxaparin, a generic version of Lovenox that is used to prevent and treat deep vein thrombosis, and to support the treatment of acute coronary syndromes; M356, a technology-enabled generic version of Copaxone, which is used for the reduction of the frequency of relapses in patients with relapse-remitting multiple sclerosis; and M118, an anticoagulant. The company also involves in developing generic or biosimilar glycoprotein products. Momenta Pharmaceuticals has collaborations with Sandoz AG and Sandoz Inc. to develop and commercialize injectable enoxaparin. The company was formerly known as Mimeon, Inc. and changed its name to Momenta Pharmaceuticals, Inc. in September 2002.

Kyowa Hakko Kirin Co., Ltd., formerly KYOWA HAKKO KOGYO CO., LTD., is a Japan-based manufacturer that has five business segments. The Medical Product segment is engaged in the manufacture, sale and promotion of medical products for hospital use, as well as the provision of technologies for antibody drug creation, the development of candidate substances for new drugs and the supply of clinical test reagents. The Biochemical segment offers medical and industrial materials, mainly amino and nucleic acids, as well as healthcare items and products for agriculture and fishery uses. It also designs and constructs facilities. The Chemical Product segment provides solvents, plasticizers, materials for plasticizers and functional products, among others. Its Food segment supplies seasonings, materials for confectionery and bread making, processed food products and others. The Others segment is involved in the wholesale and distribution businesses, as well as the provision of industrial alcohol.

The health care products subsidiary of Bayer AG, Bayer HealthCare develops and manufactures products for humans and animals. Bayer HealthCare operates through four divisions: Pharmaceuticals (represented by Bayer Schering Pharma and Bayer Healthcare Pharmaceuticals); Consumer Care (OTC medications); Animal Health (veterinary drugs); and Medical Care (diagnostic equipment makers including Diabetes Care and MEDRAD). Bayer HealthCare's better-known products include YAZ birth control pills, antibiotic Avelox, erectile dysfunction treatment Levitra, Bayer Aspirin, Alka-Seltzer, One-A-Day vitamins, and the flea preventative Advantage.

Viventia Biotechnologies Inc., a biopharmaceutical company, offers a portfolio of novel antibody-based drugs for the treatment of cancer. Its lead product, Proxinium is used for the treatment of head and neck cancer. The company also offers Vicinium, a product for the treatment of bladder cancer; and VB6-845, a product for the treatment of solid tumors. Viventia specializes in the discovery and development of a portfolio of monoclonal antibodies for the treatment of common cancers. It also has a location in Winnipeg, Canada. The company was formerly known as Novopharm Biotech, Inc. and changed its name to Viventia Biotech, Inc. in 2000. The company was is headquartered in Mississauga, Canada. As of December 28, 2005, Viventia Biotechnologies Inc. operates as a subsidiary of Dan Family Holdings, Ltd.

XDx, Inc. operates as a molecular diagnostics company which focuses on discovering, developing, and commercializing noninvasive gene expression-based tests for the monitoring of transplant rejection and autoimmune diseases. It focuses on immune-mediated conditions that require life-long monitoring and testing to avoid or to respond to serious complications. The company offers the AlloMap HTx molecular expression test to monitor heart transplant recipients for acute cellular rejection. It is also developing a gene expression-based test, the AlloMap LTx molecular expression test, to monitor for acute cellular rejection in lung transplant recipients. In addition, the company engages in designing a clinical study to create a gene expression test to monitor for disease flares in patients affected by systemic lupus erythematosus. The company was formerly known as Expression Diagnostics, Inc. and changed its name in July 2002. The company is was incorporated in 1998 and is based in Brisbane, California.

Manhattan Pharmaceuticals, Inc. company was founded in 2001 and is based in New York, New York. Manhattan Pharmaceuticals, Inc., a development stage biopharmaceutical company, engages in the development and commercialization of pharmaceutical therapies in the United States. Its product candidates under development include Hedrin, a novel, non-insecticide treatment for pediculosis; and Topical PTH (1-34) for the treatment of psoriasis. Manhattan Pharmaceuticals has a joint venture agreement with Nordic Biotech Advisors ApS to develop and commercialize Hedrin.

Targeted Genetics is putting the bull's-eye on disease. The drug developer is working in the promising (though as yet unproven) field of gene therapies, drugs that deliver particular DNA sequences into targeted cells to encourage (or sometimes inhibit) the production of proteins associated with disease. The company's drug candidates -- targeting conditions such as retinal dystrophies, lateral sclerosis, HIV/AIDS, heart failure, and Huntington's disease -- employ proprietary technology using bio-engineered viral cells (called vectors) to deliver the genes. The company is working on its own to develop therapies for certain candidates and with development partners on some other programs.

Bioniche Life Sciences is seeking its niche in the development of drugs for both humans and animals. The firm has three divisions: Human Health, Animal Health, and Food Safety. The Bioniche Animal Health division sells products to improve livestock breeding and to boost livestock immunity without antibiotics. Bioniche's Food Safety division works to improve food and water quality by developing technology to prevent infections and diseases in animals that are passed on to humans. The company's Bioniche Therapeutics segment is developing pharmaceuticals to help humankind; it focuses on urology, oncology, and immune system disorders.

Immtech Pharmaceuticals, Inc. company was founded in 1984 and is based in New York, New York. mmtech Pharmaceuticals, Inc. focuses on the discovery and development of drugs to treat infectious diseases worldwide. The company involves in drug discovery and development programs for hepatitis C and malaria; and provides aromatic cationic pharmaceutical compounds. It also offers assistance to healthcare companies seeking to conduct clinical trials, and manufacture and/or distribute pharmaceutical products in China. In addition, the company involves in investing in metal and mineral assets, primarily tin assets in China.

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