Johnson & Johnson subsidiary Ortho-McNeil Pharmaceutical, Ortho Dermatologics makes a variety of prescription dermatological potions, including topical creams and injectables used to treat acne, fungal infections, and damage caused by sun exposure and aging. The firm's RETIN-A MICRO ointment, which was developed by AP Pharma, treats acne; and anti-wrinkle cream Renova reduces fine lines brought on by sun exposure. Other products target athlete's foot and promote wound healing.

Neurocrine Biosciences, Inc. was founded in 1992 and is based in San Diego, California. Neurocrine Biosciences, Inc. engages in the discovery and development of drugs for the treatment of neurological and endocrine-related diseases and disorders in the United States. The company develops drugs for endometriosis, anxiety, depression, pain, diabetes, irritable bowel syndrome, insomnia, and other neurological and endocrine related diseases and disorders. Its products in clinical development comprise Elagolix, a Phase II product for Endometriosis; CRF1 Antagonist, a phase II product for mood disorders; CRF2 Peptide Agonist, a phase II drug for Cardiovascular related diseases; CRF1 Antagonist, a Phase I product for treating Mood Disorders and Irritable Bowel Syndrome; and Elagolix, a Phase I product for treating Benign Prostatic Hyperplasia and Uterine Fibroids. The company's research programs include Vesicular Monoamine Transporter 2 Inhibitor for movement disorders and schizophrenia; Glucose Dependent Insulin Secretagogues for type II diabetes; Antiepileptic drugs for epilepsy and bipolar disorder; and GnRH Antagonists for hormone dependent diseases and oncology. It has strategic alliances with GlaxoSmithKline to develop and commercialize CRF antagonists for psychiatric, neurological, and gastrointestinal diseases; and Dainippon Sumitomo Pharma Co. Ltd. to develop and commercialize indiplon in Japan.

AlphaRx, Inc., a pharmaceutical company, engages in the research and development of therapeutic products in Canada. The company is developing novel formulations of existing drugs that are insoluble or poorly soluble in water, utilizing its proprietary Bioadhesive Colloidal Dispersion drug delivery systems. Its principal products include Indaflex, a topical cream for the treatment of osteoarthritis of the knee; and Zysolin, an inhaled Tobramycin nanoparticles intended for the adjunctive treatment of Pseudomonas aeruginosa pneumonia in intubated and mechanically-ventilated patients. Indaflex completed a Phase II Proof of Concept clinical trial and Zysolin is in pre clinical stage. The company was formerly known as Logic Tech International, Inc. and changed its name to AlphaRx, Inc. in January 2000. AlphaRx, Inc. was founded in 1997 and is based in Markham, Canada.

CorMedix believes the way to a healthy heart is through the kidney -- and vice versa. The biopharmaceutical company develops medications for the treatment and prevention of cardiorenal disease (kidney and related cardiac dysfunctions), including a liquid and gel used to prevent infection and clotting which can occur during intravenous treatments, such as dialysis and chemotherapy. Also, in an agreement with Shiva Biomedical, the company is developing a new formulation of the drug deferipone, to be used in the prevention of kidney damage in high-risk patients. The company expects to market its products worldwide. CorMedix, controlled by a group of its officers, filed to go public in November 2009.

The Quigley Corporation company was founded in 1989 and is headquartered in Doylestown, Pennsylvania. The Quigley Corporation is a manufacturer, marketer and distributor of a diversified range of homeopathic and health products which comprise the Cold Remedy and Contract Manufacturing segments. The Company is also involved in the research and development of potential natural base health products, including, but not limited to, prescription medicines along with supplements and cosmeceuticals for human and veterinary use, which comprise the Ethical Pharmaceutical segment. Cold-Eeze is one of the Company’s primary cold remedy over the counter (OTC) products. The Cold Remedy segment, where Cold-Eeze is represented, is reviewed regularly to realize any new consumer opportunities in flavor, convenience and packaging to help improve market share for the Cold-Eeze product. The Company’s customers include a range of large wholesalers, mass merchandisers, and multi-outlet pharmacy chains.

Carma Laboratories, Inc. company was founded by Alfred Woelbing, who developed the formula for Carmex in 1937 as a treatment for his own cold sores. Carma Laboratories wants to make it easier for you to smile and sit. The family-owned-and-operated company is most famous for its retro yellow-lidded vials of Carmex lip balm. The company also makes Am-Ren, a zinc-oxide based diaper rash ointment, and LANEX hemorrhoid ointment to soothe cracked and painful tissues elsewhere. Once sold mostly in the Midwest and the ski areas of the Rockies, Carmex soothes lips in all 50 states, Canada, Australia, and Europe.

DiagnoCure Inc. company was founded in 1994 and is headquartered in Quebec City, Canada. DiagnoCure, Inc., a life sciences company, engages in the research, development, production, and commercialization of diagnostic tests for the detection and management of cancers in Canada. It focuses on colon, prostate, breast, and lung cancers. The company provides ImmunoCyt /uCyt+, a tool for the diagnosis and monitoring of bladder cancer; uPM3, a noninvasive test for the detection of prostate cancer; and molecular diagnostic tests for lung cancer. It also offers Previstage GCC colorectal cancer staging test for the management of colorectal cancer. The company holds worldwide diagnostic and therapeutic rights for the use of the PCA3 technology in prostate cancer diagnosis. DiagnoCure has a strategic alliance with Gen-Probe Incorporated for the development and commercialization of diagnostic products using the DiagnoCure PCA3 gene technology for prostate cancer.

Lifecore Biomedical hopes to help bodies plump up, smooth out, and keep moving. Lifecore's hyaluronan division makes products using hyaluronan, a natural lubricating compound found in animal and human connective tissues. The products are used in cataract surgeries, bone grafting, pain treatments for osteoarthritis, and veterinary orthopedics. Hyaluronan is also being tapped for use in cosmetic procedures as a dermal filler (to smooth out wrinkles). Lifecore has supply agreements with Alcon to use its hyaluronan solution in cataract surgery products. In 2008 the firm was taken private by Warburg Pincus.

Hoffmann-La Roche, Inc., also known as Roche, is a research-oriented pharmaceutical company. It provides medications in the areas of infectious diseases, metabolic diseases, neurology, oncology, transplantation and virology, AIDS, cardiovascular diseases, central nervous system disorders, and dermatology. Hoffmann-La Roche, Inc. was formerly known as Roche Chemical Works and changed its name to Hoffmann-La Roche Inc. in January 1929. The company was founded in 1905 and is headquartered in Nutley, New Jersey. It has research centers in Basel, Switzerland; Nutley, New Jersey; Penzberg, Germany; Shanghai, China; and Palo Alto, California. Hoffmann-La Roche, Inc. operates as a subsidiary of Roche Holding AG.

Stiefel Laboratories, Inc. company's products treat a variety of dermatological ailments including acne, psoriasis, and even warts. Among the company's prescribed products are Duac and Brevoxyl acne medications and rosacea treatment Rosac. Stiefel also makes such over-the-counter remedies as fungal infection treatment Zeasorb and Sarna Lotion for itchy skin. Through subsidiaries, the company has manufacturing, marketing, and research operations in more than 30 countries, and markets it products in more than 70 countries. Founded in 1847, the company was owned by the Stiefel family before being acquired by GlaxoSmithKline in 2009.

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