Cubist was founded in 1992 and is headquartered in Lexington, Massachusetts. Cubist Pharmaceuticals, Inc. operates as a biopharmaceutical company focused on the research, development, and commercialization of pharmaceutical products that address unmet medical needs in the acute care environment. The company markets CUBICIN (daptomycin for injection), the first antibiotic in a new class of anti-infectives called lipopeptides in the United States. It began promoting MERREM I.V. (meropenem for injection) in the U.S. in July 2008. MERREM is an established spectrum antibiotic developed by AstraZeneca. The Cubist product pipeline includes ecallantide, a recombinant human protein in Phase 2 clinical trials; CONSERV-1 and CONSERV-2 for the reduction of blood loss during cardiac surgery; and two Phase 1 programs that address unmet medical needs, one in CDAD (Clostridium difficile-associated diarrhea) and the other in multi-drug resistant (MDR) Gram-negative infections. In addition, the company, in collaboration with Alnylam Pharmaceuticals, Inc., has a pre-IND and a Phase 2 program underway in novel treatments for respiratory syncytial virus infections using Alnylam's RNA-interference technology.

Athersys, Inc., is a biopharmaceutical company engaged in the discovery and development of therapeutic products. Through the application of its technologies, the Company has established a pipeline of therapeutic product development programs in multiple disease areas. The Company’s current product development portfolio consists of MultiStem, a patented and stem cell product that the Company is developing as a treatment for multiple disease indications, and that is being evaluated in two ongoing clinical trials. In addition, the Company are developing novel pharmaceuticals to treat indications such as obesity, certain cognitive and attention disorders, narcolepsy or other forms of excessive daytime sleepiness. In December 2008, the Company were granted authorization by the United States Food and Drug Administration (FDA), to initiate a third clinical trial, administering MultiStem for the treatment of ischemic stroke.

MerseyBIO is an incubator for young biotechnology businesses. Backed by the University of Liverpool and National Health Service, the company provides office and laboratory space, as well as business, investment, and technical support services to biotechnology entrepreneurs. MerseyBIO, which can incubate up to 15 biotechnology businesses, also networks its member biotechnology companies with other biotechnology firms and resources around the world. Provexis plc became the first flotation of a MerseyBIO-based company.

Bayer HealthCare Diabetes Care Division is sweet on its customers. Part of Bayer HealthCare's massive worldwide operations, the division markets its parent company's blood glucose monitoring systems, self-care software, and lancing devices to consumers through pharmacies, retail stores, hospitals, and wholesalers. The company manufactures the Ascensia line of blood testing systems (including the Breeze 2 and Contour monitors), which it sells in over 100 countries in Asia, Latin America, North America, and western Europe. Bayer has produced diagnostic products for diabetes since 1941 and developed the first portable blood glucose meter and test strips in 1969.

NitroMed, Inc. company has developed a technique to enhance nitric oxide and add it to drugs to improve their efficiency. Nitric oxide is formed in the body and plays a role in relaxing blood vessels, making it harder for blood platelets to stick to blood vessel walls, and thereby reducing the obstructions that lead to stroke. Its sole product, BiDil, has FDA approval and is specifically indicated for heart disease in self-identified African-Americans, a group that suffers from the disease at a higher rate than other ethnicities. NitroMed was acquired by health care investment group Deerfield Capital Management in 2009.

ImClone Systems has one drug and it is making the most of it. The drug development company's only product on the market, Erbitux, is approved for treatment of colorectal cancer, as well as head and neck cancers. ImClone Systems co-promotes the drug with Bristol-Myers Squibb in North America and with Merck KGaA elsewhere. ImClone is continuing to develop Erbitux as a possible treatment for other kinds of cancer, including lung cancer. The company is also working on additional oncology-related antibody therapies. In 2008 ImClone was acquired by Eli Lilly for $6.5 billion, after rejecting bids from Bristol-Myers Squibb.

Afexa Life Sciences (formerly CV Technologies) bets that mother nature is always right, but it offers a guarantee just in case. The company uses its ChemBioPrint technology to identify and measure the contents and biological activity of natural health products to ensure batches of herbs and natural compounds are safe and consistent. The company originated as a spin-off from the Faculty of Medicine at the University of Alberta in 1992, and now focuses on the development and manufacturing of natural health products for disease prevention and health maintenance for everyday consumers, especially athletes. COLD-fX is Afexa's lead product and works to strengthen the immune system to prevent colds and the flu.

CombinatoRx, Incorporated company was founded in 2000 and is based in Cambridge, Massachusetts. CombinatoRx, Incorporated (CombinatoRx) is a biopharmaceutical company focused on developing synergistic combination pharmaceuticals. The Company has devoted substantially all of its resources to the development of its drug discovery technology and the research and development of its drug candidates, including conducting preclinical and clinical trials and seeking intellectual property protection for its technology and product candidates. It has been advancing a portfolio of four product candidates, Synavive (CRx-102), CRx-401, CRx-191 and CRx-197, through clinical research and development, and has a number of product candidates that have either completed Phase IIa clinical trials or are in preclinical development. Its portfolio of clinical product candidates targets multiple diseases including immuno-inflammatory diseases, metabolic disease, chronic pain and topical dermatoses. In December 2009, CombinatoRx and Neuromed Pharmaceuticals Inc. announced that they have merged.

Omrix Biopharmaceuticals helps keep blood in its place in the operating room. The company develops biosealants derived from human plasma to control bleeding during surgical procedures. The biosealants contain naturally occurring proteins that clot and adhere to tissue. Johnson & Johnson's Ethicon subsidiary markets and distributes these products under the names Evicel in the US and Quixil in Europe. Omrix's Evithrom thrombin product was developed with Ethicon primarily for neurosurgery. The FDA has approved both for hemostasis (minimizing blood loss) during surgery. Omrix was acquired by Johnson & Johnson in 2008 and became part of the Ethicon division.

Peoplesway.Com, Inc., an electronic commerce and Internet services company, maintains an Internet destination called ‘Peoplesway’, located at www.peoplesway.com. The majority of the company’s goods and services are available through an alliance with DRM, Inc. and its member network of approximately 14,000 independent contractors. The Web site offers goods and services for sale, such as personal hygiene products, skin care, hair care, and bath products. In addition, DRM supplies Body Management System nutritional products, including weight loss and anti-aging supplements. DRM manufactures and packages these products through a licensing agreement with a health and beauty product manufacturer.

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