Santa Cruz, California might be known for its sun-baked bodies; Santa Cruz Biotechnology is known for its antibodies. The company makes antibodies used by researchers to identify and treat a variety of conditions. Its products include growth factor antibodies, steroid receptor antibodies, and tumor suppressor antibodies. The company also offers more than 10,000 target-specific small interfering RNA (siRNA), which are used to silence genes. Its siRNAs are designed to silence tumors suppressor proteins, cell cycle proteins, and lymphocyte signaling proteins, among others. Santa Cruz Biotechnology has offices in California, Japan, and Germany and sells its products through distributors worldwide.

Carma Laboratories, Inc. company was founded by Alfred Woelbing, who developed the formula for Carmex in 1937 as a treatment for his own cold sores. Carma Laboratories wants to make it easier for you to smile and sit. The family-owned-and-operated company is most famous for its retro yellow-lidded vials of Carmex lip balm. The company also makes Am-Ren, a zinc-oxide based diaper rash ointment, and LANEX hemorrhoid ointment to soothe cracked and painful tissues elsewhere. Once sold mostly in the Midwest and the ski areas of the Rockies, Carmex soothes lips in all 50 states, Canada, Australia, and Europe.

Roche s.r.o in the Czech Republic is just a hop, skip, and a jump away from parent company Roche Holding Ltd. in nearby Switzerland. Its operations are focused more on the parent company's diagnostic products than on its traditional pharmaceuticals; Roche s.r.o. has two facilities in Prague for manufacturing and distributing tests for Hepatitis B and C, HIV, cancer, and other diseases. One is devoted exclusively to diabetic products -- diabetes is a growing problem in the Czech Republic. Roche s.r.o. also markets pharmaceuticals made at other Roche facilities, including such popular therapies as cancer drugs Avastin and Herceptin, lymphona drug MabThera, and osteporosis drug Bonviva.

Unigene Laboratories, Inc. company was founded in 1980 and is based in Boonton, New Jersey. Unigene Laboratories, Inc., a biopharmaceutical company, engages in the research, production, and delivery of peptides for medical use primarily in the United States. The company focuses on the development of calcitonin and other peptide products for the treatment of osteoporosis and other indications, including nasal and oral calcitonin, and oral parathyroid hormone (PTH). It offers Fortical, a nasal calcitonin product for the treatment of postmenopausal osteoporosis. Unigene Laboratories has licensing agreements with GlaxoSmithKline to develop an oral formulation of an analog of PTH; Upsher-Smith Laboratories, Inc. to market Fortical; Novartis Pharma AG to manufacture calcitonin; and Shijiazhuang Pharmaceutical Group for research, development, and manufacture of recombinant salmon calcitonin and non-oral PTH.

ARCA biopharma, Inc. (ARCA), formerly Nuvelo, Inc. is a biopharmaceutical company focused on developing genetically-targeted therapies for heart failure and other cardiovascular diseases. ARCA’s lead product candidate Gencaro (bucindolol hydrochloride), a beta-blocker and mild vasodilator is under review by the United States Food and Drug Administration (FDA), for chronic heart failure (HF). Gencaro is an oral tablet formulation, dosed twice daily. On January 27, 2009, Nuvelo, Inc. (Nuvelo) completed the merger with ARCA biopharma, Inc. (ABI). Pursuant to the Merger, Dawn Acquisition Sub, Inc. merged with and into ABI, with ABI continuing after the merger as the surviving company and a wholly owned subsidiary of Nuvelo. Pursuant to the Merger, ABI changed its name to ARCA biopharma Colorado, Inc. and Nuvelo changed its name to ARCA biopharma, Inc.

Medifacts was founded in 1985 as Core Laboratory Services and has facilities in the US, Germany, and China. Medifacts International, Inc. company specializes in cardiovascular safety data management services, including ECG (electrocardiogram) and ambulatory blood pressure monitoring services, for clients conducting pharmaceutical, biotech, and medical device development trials. It also provides data collection, consulting, training, and telemedicine services. The company has sold its Clinical Research Services division, which offered broader data management services for clinical trials.

Ono Pharmaceutical traces its history back to 1717, though it took its current form in 1947. Ono Pharmaceutical Co., Ltd. is a Japan-based company primarily engaged in the manufacture and sale of pharmaceuticals. The Company offers oral medication for the treatment of bronchial asthma, disturbances of peripheral circulation, chronic pancreatitis and overactive bladder, as well as injection drugs for the treatment of acute lung injury, generalized intravascular coagulation syndrome, acute phase cerebral thrombosis and blood pressure regulators used during surgical operations. The Company has four subsidiaries and two associated companies.

Nymox Pharmaceutical was founded in 1989 and is based in St. Laurent, Canada. Nymox Pharmaceutical Corporation, a biopharmaceutical company, engages in the research and development of drugs and diagnostic devices. Its products include NicAlert and TobacAlert tests that use urine or saliva to detect use of and exposure to tobacco products; and AlzheimAlert, a urinary test that aids physicians in the diagnosis of Alzheimer's disease. The company's products under development comprises NX-1207, which is in phase III trial for the treatment of enlarged prostate; NXC-4720, an antibacterial agent that is in laboratory trials for the treatment of E. coli O157:H7 bacterial contamination in hamburger meat, and other food and drink products, as well as for the treatment of urinary tract and other bacterial infections in humans; and Statins, a class of commonly prescribed cholesterol lowering drugs to treat, prevent, or reduce the risk of Alzheimer's disease. It is also in the preclinical stage of developing therapeutic products for oncological indications; and has various diagnostic markers and technologies, including a patented platform for point-of-care testing.

Rowett Research Services (RRS) will supply the technology, thanks to its research parent, the Rowett Institute. It will even throw in marketing services and project management. All RRS needs are companies interested in commercializing new ideas and products. Its primary focuses are nutrition issues and outpatient health care studies, such as antimicrobial agents and antioxidants. Founded in 1988, RRS works with public and private partners in the pharmaceutical, biotechnology, food, and agricultural industries to bring the research underway at the Rowett Institute to the marketplace.

Cellectis SA company develops technologies involving the research and development of rational genome engineering (making changes in the genetics of a cell or organism). The company's research is primarily based on the Meganucleasus, a natural classification of DNA that isolates unique breaks at key locations within living cells. Its patented Meganuclease Recombination Systems technology helps to initiate the rational genome engineering process, which in turn can help treat diseases and augment genetic codes.

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