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Broadley-James manufactures measurement and control instruments and accessories for use in bioprocess and fermentation applications. The company's BioNet product line includes a bioreactor, a controller, a motor controller, and a utility tower. Each controller can network and control several dozen bioreactors. Broadley-James was established in 1967 by Leighton Broadley (CFO), Marcile Broadley, and Richard James. James left the business in 1976. The company has operations in California and Pennsylvania, and overseas in the UK. Broadley-James is owned by its senior officers.

Bruker Corporation designs and manufactures life science and materials research systems and associated products worldwide. Its BioScience segment offers advanced instrumentation and automated solutions based on X-ray technology, OES-spark technology, mass spectrometry technology, and infrared and Raman molecular spectroscopy technologies. It offers x-ray systems, computer-controlled positioning systems, sample handling devices, and data collection and analysis software to acquire, analyze, and manage elemental and molecular information. This segment also provides mass spectrometers that measure the mass or weight of molecules, as well as offers mass spectrometry systems and integrated solutions for applications in life-science markets, including genomics, expression proteomics, clinical proteomics, metabolic and peptide biomarker profiling, drug discovery and development, molecular diagnostics research, molecular and systems biology, and basic molecular medicine research. In addition, it offers instruments for life science, pharmaceutical analysis, and food and agricultural analysis in research and development, quality control, and process analysis applications. The company's BioSpin offers life science analysis instruments based on magnetic resonance, a natural phenomenon occurring when a molecule gives off a signature radio frequency. It develops superconducting wire materials used in various applications, including power cables, motors, generators, and superconducting magnets. Bruker Corporation serves pharmaceutical, biotechnology, proteomics and molecular diagnostic, semiconductor, chemical, cement, metals and petroleum, food, beverage, and agricultural companies, as well as academic institutions, government agencies, and raw material manufacturers. The company was formerly known as Bruker BioSciences Corporation and changed its name to Bruker Corporation in February 2008. Bruker Corporation was founded in 1991 and is headquartered in Billerica, Massachusetts.

Since 1980, the Bruker Daltonics Corporation has developed as part of the global Bruker organization. The company roots were the German Bruker-Franzen Analytik GmbH and the Swiss Spectrospin AG. These companies developed mobile detectors, as well as mass spectrometers for physical chemistry. From 1990 on, the Daltonics business received new momentum: Technological innovation now allowed the analysis of fragile biomolecules. This development opened up new markets, which have been the major driving force for growth and global expansion of Bruker Daltonics through the last decade. Since 2003, Bruker Biosciences is a publicly listed company (NasdaqNM:BRKR).

Caliper Life Sciences, Inc. develops and sells products and services to pharmaceutical and biotechnology companies, and government and other not-for-profit research institutions worldwide. Its integrated systems consist of instruments, software and reagents, laboratory automation tools, and assay and discovery services. The company offers a portfolio of molecular imaging, microfluidics, automation and liquid handling technologies, and scientific applications to address various limitations in the drug discovery and development process. Its products include IVIS Imaging Systems and Living Image Software, an integrated optical molecular imaging solution; Light-Producing Cells and Microorganisms to analyze the spread and treatment of cancer and infectious diseases, as well as to study immunology; Light Producing Transgenic Animal models to analyze gene expression, protein activity, and disease progression; and luciferin, a chemical compound to produce bioluminescence, and VivoFluor fluorescent labeling kits for fluorescent imaging. The company's products also comprise LabChip 3000 Drug Discovery System, which produces data that minimizes false positives and false negatives, and detects weak inhibitors; LabChip EZ Reader, EZ Reader II, and ProfilerPro Kits; Caliper Sciclone that incorporates automated microplate carriers; Zephyr, a liquid handling instrument; staccato automated workstations for drug discovery, genomics, proteomics, and drug development laboratories; Twister I and II, which automate the movement of microplates; MultiDose G3, an automated dissolution testing system; and active pharmaceutical ingredient workstation. In addition, it offers contract research and transgenic animal services, drug discovery and development services, product support, and validation services. Caliper Life Sciences sells its products through direct sales force and a network of distributors. The company was founded in 1995 and is headquartered in Hopkinton, Massachusetts.

Cambridge Research & Instrumentation (CRi) develops and markets optical imaging systems to advance biomedical research and molecular-based drug and diagnostic development. CRi’s patented systems enable researchers and clinicians to quantitate multiple disease and drug response markers in intact tissue samples, at a cellular level or in living small animals. CRi’s products integrate a unique multispectral imaging technology with proprietary image analysis algorithms to achieve unparalleled accuracy and sensitivity, rapidly and cost-effectively. CRi’s award-winning systems include Nuance™ for multispectral imaging on brightfield and fluorescence microscopes; inForm™ automated image analysis software; Vectra™ for high-throughput slide imaging and analysis; and Maestro™ for in-vivo optical imaging.

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