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454 Life Sciences company has developed a computer-controlled instrument and related software that enable scientists to analyze whole genomes in one fell swoop, rather than a few hundred genes at a time. Parent company Roche Diagnostics distributes 454 Life Sciences' Genome Sequencing Systems to clinical laboratories, research departments of drugmakers, and other customers worldwide. Research fields include cancer and infectious disease, drug discovery, and paleontology. The company's 454 Sequencing Center provides sequencing services directly.

AAIPharma provides contract research services to the pharmaceutical, biotech, and medical device industries. Its outsourcing services run the gamut from drug candidate selection and feasibility studies, to bioanalytical testing and clinical trials management. Its early clinical development division helps evaluate potential compounds and design patient studies. The company's clinical development businesses run large clinical trials for customers around the world. Other services include regulatory support and data management. AAIPharma has divested its pharmaceutical development division, which cranked out small batches of drugs to supply clinical trials and develops oral drug delivery technology.

Aastrom Biosciences, Inc. company was founded in 1989 and is headquartered in Ann Arbor, Michigan. Aastrom Biosciences, Inc. is a regenerative medicine company and focuses on the clinical development of autologous cell products for the repair or regeneration of multiple human tissues, based on its Tissue Repair Cell (TRC) technology. The Company’s preclinical and clinical product development programs utilize patient-derived bone marrow stem and early progenitor cell populations and are investigated for their ability to aid in the regeneration of tissues, such as cardiac, vascular and bone. TRC-based products have been used in over 350 patients, and its stages of development are Cardiac regeneration includes Cardiac Repair Cells (CRCs); Dilated cardiomyopathy (DCM) (severe heart failure); Vascular regeneration includes Vascular Repair Cells (VRCs); Critical limb ischemia (CLI); Bone regeneration includes Bone Repair Cells (BRCs); Osteonecrosis of the femoral head; Non-union fractures, and Maxillofacial.

Abraxis BioScience, Inc. (Abraxis) is an integrated biotechnology company. The Company is engaged in the discovery, development and delivery of next-generation therapeutics and core technologies that offer patients treatments for cancer and other critical illnesses. The Company’s portfolio includes protein-based nanoparticle chemotherapeutic compound (Abraxane), which is based on its tumor targeting technology known as the nab technology platform. Abraxis owns the worldwide rights to Abraxane, a next-generation, nanometer-sized, solvent-free taxane that was approved by the United States Food and Drug Administration (FDA) in January 2005 for its initial indication in the treatment of metastatic breast cancer and launched in February 2005. The Company’s product pipeline includes over five clinical oncology and cardiovascular product candidates in various stages of testing and development, including Abraxane and Coroxane for various indications.

Acadia Pharmaceuticals Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of small molecule drugs for the treatment of central nervous system disorders. The Company is developing a portfolio consisting of its four product candidates, including pimavanserin, which is in Phase III development for the treatment of Parkinson’s disease psychosis. In addition, the Company has a product candidate in Phase II for chronic pain and a product candidate in Phase I for glaucoma, both in collaboration with Allergan, Inc., and ACP-106 in IND-track development. The Company’s product candidates include Pimavanserin, AGN-XX/YY, AC-262271 and ACP-106. The Company maintains two wholly owned subsidiaries: ACADIA Pharmaceuticals AB based in Malmo, Sweden and ACADIA Pharmaceuticals A/S based in Denmark.

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