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Elekta AB(publ) manufactures the Gamma Knife -- which isn't a knife at all but a chamber that delivers radiation therapy to treat tumors and cancer in the brain. The Gamma Knife was invented in 1968 by Elekta's founder, Dr. Lars Leksell, the father of radiosurgery. The company manufactures other non-invasive treatment systems, such as image-guided radiation therapy (IRGT) and particle therapy, used to treat cancer elsewhere in the body. Elekta also sells health care-related software through its two subsidiaries, CMS and IMPAC. Elekta was founded in 1972. Its products are used in more than 5,000 hospitals around the world.

Elron Electronic Industries fosters all kinds of high-tech endeavors. The conglomerate founds or invests in Israeli technology companies in a number of fields, including medical devices, semiconductors, software, telecommunications, and clean technology. It typically owns controlling or significant minority stakes in its group companies, for which it plays an active management role; it periodically spins off its offspring to realize gains for investing in new opportunities. Through subsidiary RDC, the company partners with Rafael, a research unit of the Israeli Ministry of Defense, to adapt Rafael-produced technologies for non-military uses.

Empi empathizes with patients who have pain, swelling, spasms, and muscle weakness. The company makes and markets a wide range of medical products, including non-pharmaceutical pain management and orthopedic electrotherapy devices. Empi's product brands include the Saunders cervical traction device used for spinal decompression therapy, the SporTX electrotherapy device for injury swelling reduction, and Minnova, a device that stimulates the pelvic floor to treat urinary incontinence. Empi sells to rehabilitation clinics and medical device distributors nationwide, as well as abroad. The company is a division of medical device maker DJO.

The development-stage medical device company,EnteroMedics Inc. uses neuroblocking technology called VBLOC therapy to combat obesity. Its initial product in development, the Maestro System, is a device laparoscopically implanted near the diaphragm that uses electrical impulses to limit the expansion of the stomach, thereby producing a feeling of prolonged fullness. The Maestro System is in US and international clinical trials, with FDA approval and commercial sales anticipated by 2010. EnteroMedics plans to build a direct sales force to market the product to bariatric surgeons and weight management specialists.

The global medical equipment company,Esaote S.p.A. makes and markets diagnostic imaging systems, with special expertise in ultrasound scanners and dedicated MRI machines (which are designed to take images of joints and limbs). Esaote also makes modular electrocardiograph systems that map the electrical activity of the heart. Its Ebit AET unit develops picture archiving and communications software for digital radiology and interventional cardiology labs. Formerly a unit of medical conglomerate the Bracco Group, Esaote is now owned by a private investor consortium led by Italy's Intesa Sanpaolo. At the company's helm is CEO Carlo Castellano, who also owns a stake in the firm.

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