She is best known for her roles in the Telugu films Shiva Manasulo Shruti and Routine Love Story.

Regina's mother tongue is Tamil. She started anchoring when she was four for Splash, a kids' channel and then moved on to work in commercials.

she shot for her first film, Kanda Naal Mudhal directed by V. Priya, which also starred Prasanna, Laila and Karthik Kumar.

Regina was next seen in the Kannada film Suryakaanti by director K. M. Chaitanya of Aa Dinagalu fame.

In 2012, she appeared in Shiva Manasulo Shruti by Tatineni Sathya, which was a remake of the 2009 Tamil film Siva Manasula Sakthi.

She was next seen in the Telugu romantic-comedy, Routine Love Story, alongside Sundeep Kishan, which she signed even before her first release in Telugu.

2013 she had two Tamil releases, Kedi Billa Killadi Ranga by Pandiraj, in which she was one of the two lead actresses, and Nirnayam.

Kotha Janta directed by Maruthi was her first 2014 release. She received positive response for her performance in the film.

She is working opposite Nara Rohith under the direction of Tatineni Satya in Sankara.

she has also bagged the female lead role opposite Sai Dharam Tej in his upcoming film to be directed AS Ravi Kumar Chowdary.

Regina is also working on Power in which she is playing a Bengali girl.